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Adverse Reactions (An Introduction)

  • When starting your child on a new medication, parents and caregivers should know potential adverse reactions associated with the medication.

  • Before learning about adverse reactions, it's important to understand the different types of adverse reactions.


What is an Adverse Reaction?

  • An adverse drug reaction is a response to a medication which is unintended and potentially harmful.

  • Adverse reactions can be broken down into 2 categories: “Predictable” or “Unpredictable”.

Predictable

Unpredictable

  • Side effects

  • Interactions

  • Toxicity

  • Allergic

  • Idiosyncratic

Predictable

  • Expected due to what we know about the drug.

  • Usually the most common and least harmful.

  • Will usually stop when the medication is discontinued.

Side Effects

Drug-Drug Interactions

Drug-Disease Interactions

Drug-Food Interactions

Toxicity


Unpredictable

  • Not expected from what we know about the drug.

  • Rare and potentially more harmful.

Allergic

  • Rash/hives due to a penicillin (antibiotic) allergy

  • Angioedema (sudden swelling) due to a blood pressure medication such as lisinopril or enalapril.

(please note that is not an exhaustive list - just a list of examples)

Idiosyncratic


Why does it matter?

Risk vs. Benefit

If you know that your child is experiencing a common (non-severe) side effect (ex: tremors & increased heart rate from albuterol), usually the benefits of the medication will outweigh the unwanted effects.

If your child is experiencing effects that are not expected and/or severe, it is time to get in contact with your child’s medical provider or seek additional medical attention. In this case, you should have a discussion with your child’s medical provider about how the benefit might not outweigh the risks.


Bottom Line

  • Adverse reactions can be split into two general categories: predictable and unpredictable.

  • Each category is defined by how common the reaction is and severity.

  • Knowing the differences between each can help determine when you should seek further medical attention.


Disclaimer

The information in this database regarding prescription drugs is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interaction or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate, or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment







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